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Amphetamine is understood to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit a variety of P450 isozymes and various enzymes hasn't been sufficiently elucidated. In vitro experiments with human microsomes suggest minimal inhibition of CYP2D6 by amphetamine and small inhibition of CYP1A2, 2D6, and 3A4